A Review on Hepatotoxic Effects of Methotrexate Therapy with Possible Strategies that May Counteract Hepatotoxicity

Methotrexate, inhibitor of a dihydrofolate reductase, is chemotherapeutic treatment applied in many kinds tumors as an anti-metabolite. also, Methotrexate to treat different other disorders, including diseases autoimmunity, such psoriasis, rheumatism, vasculitis and ulcerative colitis Crohn’s disease. However, induces toxic effects on neurons, kidney toxicity, liver damage, also have been associated with elevation risk hepatic injury, fibrosis cirrhosis. work dihydrofolic acid analog that binds the reductase enzyme prevent synthesis tetrahydrofolic acid, essential DNA. Although folic combine therapy hepatotoxic effects, may reduce therapeutic so recent research focus incorporation new agent counteract induced hepatotoxicity include vitamin B12, E, N-acetylcysteine, melatonin, Erdosteine, inulin, Ferulic Human placental extract, Natural plant extract (flavonoids). These agents are promising hepatotoxicity. Materials methods: A comprehensive literature review published articles methotrexate was carried out by electronic Medline, PubMed, Google scholar, Cochrane Libran data bases using searching terms related prevention The article focusses clinical studies regions period 2018-2022. Objective: To search for update modality preventive damage Results: Recent study oriented